RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-214
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; immunohistochemistry etc.
Target
MFN2
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts
Year
2015
Function
"miR-214 mediates cardiac fibroblast (CF) proliferation and collagen synthesis via inhibition of MFN2 and activation of ERK1/2 mapk signalling, downregulation of miR-214 by antagonists attenuated the proliferation and collagen synthesis."